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Explore the world of PyScript and Pyodide in this 39-minute PyCon US talk by Nicholas H. Tollervey and Paul Everitt. Dive into the intricacies of running Python in the browser, understanding the architectural challenges and opportunities it presents. Learn how PyScript works and examine key technical issues for developing web applications with the WebAssembly version of Python. Discover the nuances of concepts like "file" in this context, explore installation processes, and understand the role of web workers in your application architecture. Engage in a lively discussion about the evolving landscape of PyScript and its implications for web development with Python.