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Explore the evolving landscape of Python packaging in this 23-minute PyCon US talk by Jeremy Paige. Delve into the changes that have occurred since the introduction of pyproject.toml five years ago, and learn why setup.py's role is diminishing. Discover alternative tools and approaches for setting up Python projects in 2021. Gain insights into the future of Python packaging and how to adapt your development practices accordingly. Access the accompanying slides for a comprehensive overview of the discussed topics and best practices.