Super-silencer Perturbation by EZH2 and REST Inhibition Leads to Large Loss of Gene Repression

Explore a 16-minute conference talk on super-silencer perturbation and its effects on gene regulation. Delve into the research presented by Seng Chuan Tang at the International Centre for Theoretical Sciences, focusing on the interdisciplinary aspects of chromatin organization. Learn how inhibition of EZH2 and REST leads to significant changes in gene expression. Gain insights into the complex world of epigenetics, 3D chromatin organization, and spatio-temporal gene regulation. Understand how this research contributes to the broader field of chromatin studies, which integrates advances in genomics, high-resolution microscopy, and single-cell measurements. Discover the importance of multi-disciplinary approaches in unraveling the principles behind chromatin organization and gene regulation.