Explore a keynote address from the SKSI 2022 Conference focusing on the future of early stroke recovery. Delve into Dr. Dale Corbett's presentation, which examines stroke as a leading cause of adult disability and the mission of the Johns Hopkins Sheikh Khalifa Stroke Institute to improve post-stroke recovery. Gain insights into fundamental questions surrounding stroke research, time-points and goals of neural repair trials, and the critical periods for stroke recovery. Learn about environmental enrichment, enriched rehabilitation techniques, and their impact on brain activity and recovery patterns. Discover the similarities between human and rat post-stroke recovery, the importance of timing in rehabilitation, and the need for personalized approaches. Examine current limitations in upper limb therapy dosage and explore predictors of post-stroke recovery in animal models. Reflect on the future directions of stroke recovery research and potential innovations in the field.
Early Stroke Recovery 2050: Where Are We Headed - Keynote Address
Johns Hopkins Medicine via YouTube
Overview
Syllabus
Intro
Stroke Recovery: The Next Frontier in Stroke Research
Fundamental Questions
Time-Points & Goals of Neural Repair Trials
The AVERT Trial
How The Brain Protects Itself
Critical Periods & Stroke Recovery
Environmental Enrichment
Enriched Rehabilitation (ER)
Rat Model of Upper Limb Recovery
Timing of Rehabilitation Matters!
The Critical Period for Stroke Recovery
Critical Period After Stroke Study (CPASS)
Is Enrichment Really Necessary?
Dissecting Components of ER
ER Increases Cortical FosB Activity
ER Produces Late Activation of Rubrospinal Circuits
Doses of Human UL Therapy Are Too Low
Humans & Rats Show Similar Patterns of Post-Stroke Recovery
Predictors of Post-Stroke Recovery in Rats
Poststroke Recovery: One Size Does NOT Fit All
What Does the Future Hold?
Taught by
Johns Hopkins Medicine
