Quiescent Yeast: A Cellular Model of Chromatin Architecture Across Scales

Explore a fascinating talk on quiescent yeast as a cellular model for chromatin architecture across scales. Delve into the research presented by Sarah Swygert at the Workshop on "Chromatin Modeling: Integrating Mathematics, Physics, and Computation for Advances in Biology and Medicine" held at the Erwin Schrödinger International Institute for Mathematics and Physics. Discover how quiescence, a reversible state where cells exit the cell cycle and suspend most cellular processes, leads to extensive chromatin condensation. Learn about the use of Micro-C, a high-resolution variation of Hi-C, to uncover the mechanisms behind chromatin condensation in quiescent budding yeast. Understand the roles of H4 tail-dependent local chromatin fiber folding and condensin-mediated chromatin loop domains in this process. Explore how disrupting these structures affects transcriptional repression. Gain insights into why quiescent yeast serves as an excellent model for studying in vivo chromatin conformations and functions at high resolution. Consider the potential applications of this system in testing models of chromatin folding and loop extrusion in cells.