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Explore groundbreaking research on the connection between gut microbiota and autism in this 27-minute conference talk from the AAAS Annual Meeting. Discover the pioneering open-label clinical trial of microbiota modification that led to significant improvements in gastrointestinal symptoms and behavior in autism patients, with benefits persisting two years post-treatment. Delve into the multi-omic approach used to identify microbes, pathways, genes, and metabolites potentially responsible for the trial's success, and learn about potential biomarkers and treatment targets. Gain insights into autism spectrum disorders, colonization resistance, and the role of Puresole in the study. Examine future research directions, parent feedback, ecosystem restoration, and the impact of dietary interventions in autism treatment.