Explore the intricacies of Ristocetin Tests in this informative 15-minute hematology video. Delve into the Ristocetin cofactor assay and Ristocetin-induced platelet aggregometry (RIPA), essential tools for measuring platelet aggregation and assessing platelet function. Learn how these tests complement other diagnostic methods like platelet count and bleeding time in evaluating thrombocytopenia, thrombocytosis, and overall platelet functionality. Gain valuable insights into the role of Ristocetin Tests in hematological assessments and their significance in diagnosing various blood disorders.
Overview
Syllabus
Ristocetin Tests | Hematology
Taught by
Medicosis Perfectionalis
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Ristocetin tests are vital in hematology for diagnosing von Willebrand disease (vWD) and other platelet function disorders. Ristocetin, an antibiotic, induces platelet agglutination by promoting the binding of von Willebrand factor (vWF) to platelet glycoprotein Ib (GPIb). The Ristocetin Cofactor Assay (RCo) measures the ability of vWF to support platelet aggregation. If vWF is deficient or dysfunctional, as seen in vWD, agglutination is impaired. Ristocetin-induced platelet aggregation (RIPA) also evaluates platelet response to ristocetin. These tests are essential for differentiating between various subtypes of vWD and other platelet-related conditions.
