Explore the results of the ADAPT trial comparing hypertonic saline and mannitol for treating severe traumatic brain injury in children in this 29-minute World Shared Practice Forum podcast. Gain insights into the evolution of pediatric TBI management, understand the study design and key outcomes, and learn about the comparative effects of these treatments on intracranial pressure. Discover the challenges and limitations of the study, and understand its potential impact on pediatric traumatic brain injury management. Published by OPENPediatrics on April 25, 2022, this podcast features Dr. Patrick Kochanek discussing the trial's findings published in JAMA Open Network. Enhance your knowledge with references to key studies in the field and prepare to apply these insights to improve care for critically ill children with severe TBI.
Results of Hypertonic Saline or Mannitol Clinical Trial for Treatment of Children with Severe TBI
Overview
Syllabus
- Kochanek PM, Adelson PD, Rosario BL, et al. Comparison of Intracranial Pressure Measurements Before and After Hypertonic Saline or Mannitol Treatment in Children With Severe Traumatic Brain Injury. JAMA Netw Open. 2022;53:e220891. Published 2022 Mar 1. doi:10.1001/jamanetworkopen.2022.0891
- Hypothermia after Cardiac Arrest Study Group. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest [published correction appears in N Engl J Med 2002 May 30;34622:1756]. N Engl J Med. 2002;3468:549-556. doi:10.1056/NEJMoa012689
- Kochanek PM, Tasker RC, Carney N, et al. Guidelines for the Management of Pediatric Severe Traumatic Brain Injury, Third Edition: Update of the Brain Trauma Foundation Guidelines [published correction appears in Pediatr Crit Care Med. 2019 Apr;204:404]. Pediatr Crit Care Med. 2019;203S Suppl 1:S1-S82. doi:10.1097/PCC.0000000000001735
- Khanna S, Davis D, Peterson B, et al. Use of hypertonic saline in the treatment of severe refractory posttraumatic intracranial hypertension in pediatric traumatic brain injury. Crit Care Med. 2000;284:1144-1151. doi:10.1097/00003246-200004000-00038
- Kumar SA, Devi BI, Reddy M, Shukla D. Comparison of equiosmolar dose of hyperosmolar agents in reducing intracranial pressure-a randomized control study in pediatric traumatic brain injury. Childs Nerv Syst. 2019;356:999-1005. doi:10.1007/s00381-019-04121-3
- Polderman KH. Mechanisms of action, physiological effects, and complications of hypothermia. Crit Care Med. 2009;377 Suppl:S186-S202. doi:10.1097/CCM.0b013e3181aa5241
Taught by
OPENPediatrics
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