Explore evidence-based medicine (EBM) and critical assessment techniques for evaluating journal articles in this 40-minute lecture from The Royal College of Pathologists. Gain insights into the hierarchy of evidence, grading systems, and approaches to analyzing published work. Learn how to apply evidence-based laboratory medicine (EBLM) for problem-solving and implementing new laboratory tests. Discover the research and development (R&D) process in laboratory contexts, including the identification of new biomarkers and regulatory considerations. Examine professional opportunities for Chemical Pathologists and laboratory personnel in R&D. Delve into topics such as critical appraisal methods, hierarchy of evidence models, grading of clinical evidence, and the integration of EBLM principles into routine practice. Understand the biomarker validation approach, R&D flowcharts in laboratories, and the qualification process for biomarkers. This comprehensive lecture provides essential knowledge for continuing professional development (CPD) programmes and various laboratory roles.
Overview
Syllabus
Intro
Learning objectives
1. What is EBM
What steps are involved in EBM?
2. Introduction to critical appraisal
Detailed Critical appraisal of a Journal Article
Core questions for initial evaluation of a scientific article
Critical appraisal - modes of research
Hierarchy of evidence - Traditional levels
Hierarchy of evidence - Grading
Grading of clinical evidence
Hierarchy of evidence and corresponding databases
Proposed new pyramid
What about qualitative research?
EBM vs EBP
Key steps in evidence-based practice
Clinical reasoning and critical appraisal
Practice of high-value evidence based laboratory medicine
Introducing the principles of EBLM into routine practice
How to apply EBLM when evaluating new laboratory tests
Biomarker validation approach
R&D flowchart in the lab
R&D process in the lab for new biomarkers
Qualification of Biomarkers
Chemical Pathologist roles involved in Research and Development
Taught by
The Royal College of Pathologists
