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Explore the groundbreaking impact of the President's Emergency Plan for AIDS Relief (PEPFAR) in this 50-minute conference talk from The Aspen Institute. Delve into the initiative's 20-year history, examining how the largest single-disease investment by any nation has saved over 25 million lives through comprehensive HIV testing, prevention, and treatment programs. Gain insights from key figures behind PEPFAR's creation: Tony Fauci, former NIAID director who conceptualized the strategy, and Bill Frist, former US Senate majority leader who facilitated its legislative approval. Understand the origins, implementation, and ongoing importance of this $110 billion commitment in the global fight against HIV/AIDS. Recorded as part of Aspen Ideas: Health 2023, this talk highlights the significance of continued support for this life-saving initiative.