Osteomyelitis - Causes, Symptoms, and Pathophysiology of Bone Infection

Explore the causes and symptoms of osteomyelitis in this 22-minute medical lecture. Learn about pyogenic and non-pyogenic bone infections, with a focus on Staphylococcus aureus and Mycobacterium tuberculosis as common causative organisms. Understand the pathophysiology of osteomyelitis, including routes of entry such as hematogenous spread, direct extension from soft tissue infections, and direct implantation. Discover the significance of metaphyseal involvement in children's long bones and the development of Pott's disease in adults. Examine the mechanisms behind diabetic foot ulcers and their progression to osteomyelitis. Gain insights into how bacteria destroy periosteum through damaging enzymes, inflammation, and oxygen free radicals. This lecture provides essential knowledge for medical students and healthcare professionals studying bone infections and their clinical implications.