Onco-Golgi and ER Stress - Drivers of Prostate Cancer Progression

Explore the intricate relationship between prostate cancer progression, endoplasmic reticulum stress, and Golgi morphology impairment in this 31-minute webinar presented by Dr. Armen Petrosyan. Delve into the self-activation mechanism of ATF6-mediated ER stress caused by Golgi disorganization and its association with enhanced androgen receptor transactivation in prostate cancer cells. Gain insights into the mechanism of abnormal glycosylation of integrins, examining the impact of Golgi disorganization on golgin distribution and N-glycosylation enzymes. Investigate the effects of ATF6-mediated ER stress on integrin expression and trafficking to the cell surface. Discuss the potential therapeutic implications of ATF6 depletion/inhibition combined with hydroxychloroquine treatment on prostate tumor progression. Earn PACE credits by watching the webinar and following the provided instructions.