Explore the latest research on gastric microbiome and its role in gastric cancer development in this 26-minute conference talk from the 2022 Gastric Cancer Summit. Delve into compositional differences in the gastric microbiome with and without H. pylori, and examine the distribution of bacterial DNA integrations in gastric adenocarcinoma. Investigate how the presence of CagA alters the gastric microbiota composition in H. pylori-infected gerbils. Learn about the distinct gastric microbiota profiles in chronic gastritis and gastric carcinoma, and understand how gastric microbial dysbiosis is associated with gastric cancer across various stages of carcinogenesis. Explore the correlation strengths of gastric cancer-enriched and depleted bacteria with disease progression. Examine the effects of intestinal Helicobacter infection on H. pylori-induced gastric injury and the impact of iron deficiency on H. pylori-induced dysplasia. Gain insights into the "axis of evil" in H. pylori-induced gastric cancer and consider future research directions in this field presented by Dr. Richard Peek from Vanderbilt University.
Novel Frontiers of the Gastric Microbiome - 2022 Gastric Cancer Summit
Stanford Department of Medicine via YouTube
Overview
Syllabus
Intro
Compositional differences in the gastric microbiome with and without H. pylori
Distribution of operational taxonomic units (OTUS) from bacterial DNA integrations in gastric adenocarcinoma
Differences in the composition of the gerbil gastric microbiome, based on H. pylori status
Presence of CagA alters composition of the gastric microbiota, when stratified by phyla levels, in H. pylori-infected gerbils
Gastric microbiota profiles differ in chronic gastritis and gastric carcinoma
Gastric microbial dysbiosis is associated with gastric carcinoma
Gastric microbiome dysbiosis across stages of gastric carcinogenesis
Correlation strengths of gastric cancer enriched and depleted bacteria with disease progression
Heatmap annotation of gastric inflammation and injury in GF mice following human gastric transplant
Species-specific effect of intestinal Helicobacter infection on H. pylori-induced gastric injury
Iron deficiency increases H. pylori-induced dysplasia in INS-GAS mice
H. pylori increases levels of DCA under conditions of iron deficiency
Fecal microbiota analysis
H. pylori-induced gastric cancer: an axis of evil
Future Investigations
Taught by
Stanford Department of Medicine
