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Explore the cutting-edge field of genomic medicine in this comprehensive lecture on making variants of unknown significance obsolete. Delve into the latest advancements in NextGen genomic medicine as presented by experts D Roden, L Lai, and J Cooke. Learn how these developments are revolutionizing the understanding and interpretation of genetic variants, potentially transforming patient care and personalized medicine. Gain insights into the challenges of interpreting variants of unknown significance and discover innovative approaches to overcome these obstacles. Understand the implications of these advancements for cardiovascular medicine and beyond. This educational program, presented by the Houston Methodist DeBakey Heart & Vascular Center, offers valuable knowledge for healthcare professionals, researchers, and students interested in the intersection of genomics and clinical practice.