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Explore the latest insights on myocardial recovery in this comprehensive grand rounds lecture. Gain a deep understanding of clinical characteristics indicating high potential for significant cardiac improvement in advanced heart failure patients. Examine the sustainability of cardiac improvement and long-term survival after left ventricular assist device (LVAD) weaning. Analyze post-LVAD long-term outcomes and side effects in patients with improved heart function and structure. Delve into topics such as clinical research, reproducibility, predicting recovery, and the distinction between recovery and remission. Investigate proposed studies, biological reviews, and calcium homeostasis. Engage with thought-provoking questions and surprising findings in the field of cardiology.