Learn about various types of arthritis and morning stiffness in this comprehensive medical lecture that delves into the pathophysiology, clinical manifestations, and distinguishing features of different arthritic conditions. Explore the detailed characteristics of morning stiffness, including its duration, intensity, and relationship with various inflammatory conditions. Master the key differences between rheumatoid arthritis, osteoarthritis, psoriatic arthritis, and ankylosing spondylitis through detailed explanations of their pathophysiology, radiological features, and clinical presentations. Understand the immune-mediated mechanisms, synovial joint involvement, and the role of various cells and chemical mediators in rheumatoid arthritis. Gain insights into treatment approaches, including DMARDs, and learn about extra-articular complications and constitutional symptoms associated with different types of arthritis. The lecture concludes with a thorough comparison of various arthritic conditions and includes an interactive Q&A session to reinforce understanding.
Morning Stiffness in Arthritis: Comparing RA, Osteoarthritis, Ankylosing Spondylitis and Septic Arthritis
Dr. Najeeb Lectures via YouTube
Overview
Syllabus
Introduction
Contents of the lecture
Clinical Conditions Associated with RA
Introduction to Morning Stiffness
First feature of Morning Stiffness
Second feature of Morning Stiffness
Third feature of Morning Stiffness
Gelling explanation and features
Differentiation between Morning Stiffness and Gelling
Hallmark of Inflammatory Arthritis
Clinical significance of Morning Stiffness
Constitutional features of Inflammatory Arthritis
Types of Inflammatory Arthritis
Osteoarthritis Pathophysiology
Inflammation in Osteoarthritis
Inflammatory Manifestations in RA
Significance of duration in RA
Scenario-based differentiation in the duration of Morning Stiffness in RA and osteoarthritis
The duration of morning stiffness in inflammatory arthritis is a key characteristic.
Relationship of duration and intensity of morning stiffness with underlying disease
Fluctuations in Morning Stiffness
Manifestations of Morning Stiffness
Joints involved in RA
Symptoms of Patients with Inflammatory Arthritis
Improvement of symptoms of Morning Stiffness by activity
Manifestations of patients of Poly Myalgia Rheumatica
Introduction to Rheumatoid Arthritis
Definition of Rheumatoid Arthritis
Explanation of clinical manifestations of RA
Alteration of proteins during RA
Causes of genetic disposition in RA
Significance of citrullinated peptides
Immune-mediated injury of synovial joints
Difference between B cells and Plasma cells
Autoimmune response in RA
Cells accumulation at Synovial joints
Abnormal activation and proliferation of cells of Synovial joints
Synovial membrane cell types
Why does the synovial membrane not have an epithelial lining?
Process involved in immune system attack in RA
Important Chemical Mediators and Drugs Used Against Them
Introduction to DMARDs
MOA of DMARDs
Constituents of Pannus
Overview of RA
Presence of Synovial Membrane in various locations
Pathophysiology of Tenosynovitis
Non-suppurative Inflammation
Recap of the Definition of RA Rheumatoid Arthritis
Constituents of Pannus
Matrix Metalloproteinases and their roles
Pannus-induced pathological changes at synovial lining
Radiological features of RA explained
Diseases Associated with Marginal Erosions
Psoriatic arthritis clinical features
The key radiological feature of psoriatic arthritis.
Joints involved in Psoriatic arthritis
Difference between RA and Psoriatic Arthritis
Involvement of Distal Interphalangeal Joints in Inflammatory Arthritis
Recap of RA
Difference between Arthralgia and Arthritis
Constitutional features of RA
Malaise definition
Alteration of the function of the Hypothalamus by Cytokines
Extra-articular complications in RA patients
Steps involved in extra-articular complications of RA
Type III Hypersensitivity Pathophysiology
Constitutional and Articular features of RA
Underlying mechanism of swollen joints in RA and osteoarthritis
Radiological Differentiation Between Rheumatoid Arthritis and Osteoarthritis
Heberden’s Node in Distal Interphalangeal joints
Differential clinical features of RA and Osteoarthritis
Radiological differentiation between RA and Osteoarthritis
Age-related difference between RA and Osteoarthritis
Differentiating Rheumatoid Arthritis RA from Osteoarthritis based on constitutional features.
Overview of lecture
Ankylosing Spondylitis and its Clinical Features
A quick recap of all the conditions associated with morning stiffness.
Brief review.
Q&A session.
Overview of next lecture.
End of lecture.
Taught by
Dr. Najeeb Lectures
