Monitoring Intact Light Chain of Therapeutic Monoclonal Antibodies in Human Serum by LC-MS for Clinical Research

Explore a 41-minute webinar presented by Dr. Yvonne Song, Sr. Application Scientist at Thermo Fisher Scientific, on monitoring intact light chain of therapeutic monoclonal antibodies in human serum using LC-MS for clinical research. Learn about the benefits of intact light chain quantitation, including simplified workflows and faster sample preparation compared to peptide quantitation. Discover how this approach provides solutions for mAbs with limited signature tryptic peptides. Gain insights into the use of Protein L magnetic beads for selective purification of antibodies containing kappa light chains, improving isolated antibody purity. Understand the application of the Orbitrap Exploris 240 MS in this process. Participate in a live Q&A session following the presentation to deepen your understanding of this innovative technique in clinical protein research and therapeutic drug monitoring of monoclonal antibodies.