Microfluidic and Spleen-on-a-Chip Studies of Sickle Cell Disease

Explore groundbreaking research on sickle cell disease through this 31-minute webinar presented by Dr. Ming Dao, Director of MIT's Nanomechanics Laboratory. Delve into innovative microfluidic assays and spleen-on-a-chip platforms designed to investigate red blood cell degradation and splenic function in both healthy individuals and those with sickle cell disease. Gain insights into the mechanisms of RBC senescence, the impact of cyclic hypoxia and mechanical loading on cell damage, and the crucial role of the spleen in maintaining erythrocyte balance. Learn how these cutting-edge studies provide valuable understanding of anemia, splenomegaly, and acute splenic sequestration crisis in sickle cell disease, while exploring the potential for new antisickling drug efficacy testing methods.