Memory-Rich CAR T Cell Engineering by PiggyBac Transposon System for Solid Malignancies

Explore cutting-edge research on CAR-T cell therapy for solid tumors in this 55-minute webinar presented by Dr. Shigeki Yagyu, a Pediatric Oncologist and Professor at Shinshu University in Japan. Delve into the development of novel piggyBac transposon (PB)-based CAR-T cells designed to overcome challenges in targeting solid malignancies. Learn about the importance of T-cell memory signatures and exhaustion-related markers in CAR-T cell products, and discover how the GMP-compliant manufacturing process generates CAR-T cells with favorable characteristics. Examine the preferential introduction of PB-transgenes into CD45RA+ peripheral blood mononuclear cells and the enrichment of stem cell memory-like CAR-T cells during expansion. Gain insights into the sustained killing activity of PB-CAR-T cells against tumor cells in vitro and their ability to debulk tumors in vivo. Understand the ongoing clinical study evaluating the safety and efficacy of PB CAR-T cells for solid tumors, and stay informed about the latest advancements in cellular immunotherapy for hematologic and solid malignancies.