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Explore the groundbreaking developments in atom control and cooling methods based on Maxwell's demon in this Stanford Physics colloquium. Delve into the innovative application of a one-way wall utilizing photon entropy, which realizes Maxwell's historic thought experiment for large ensembles. Learn how this technique is being applied as an alternative to evaporative cooling and for efficient isotope separation in medicine and basic science. Discover the work of The Pointsman Foundation, a non-profit organization dedicated to advancing these cutting-edge technologies for practical applications.