Precision Dynamical Mapping to Characterize Brain Activity Fluctuations

Explore innovative approaches to understanding the neurobiological basis of psychiatric disorders through noninvasive neuroimaging in this 59-minute lecture by Manish Saggar. Delve into the challenges of using neuroimaging to anchor psychiatric disorders in neurobiology, focusing on device noise and limited biophysical model utilization. Discover how Topological Data Analysis, particularly the Mapper algorithm, can be applied to capture evoked and intrinsic transitions in brain activity, detect changes associated with psychiatric disorders, and evaluate the effects of pharmacological interventions and neuromodulation techniques. Examine promising results and methodological advancements in Mapper's application to neuroimaging studies. Conclude by considering open questions that could lead to improved understanding of psychiatric disorders and the development of novel therapeutic strategies.