Long-read Sequencing at Scale and High Accuracy

Explore the advantages of long-read sequencing for large-scale genomic analysis in this 31-minute webinar presented by Dr. Medhat Mahmoud. Learn about the All of Us initiative's goal to sequence over one million diverse American genomes and discover how a recent technical pilot compared short-read and long-read sequencing technologies. Gain insights into the improved accuracy of HiFi reads for sequencing complex, medically relevant genes, particularly in identifying pathogenic variants and structural variations. Understand the benefits and challenges of low-coverage sequencing for large cohort studies, and explore a cloud-based pipeline optimized for long-read analysis. Discover the implications of these findings for enhancing the accuracy and efficiency of sequencing in large-scale genomic initiatives.