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Explore the importance of Earth and space science data in advancing scientific research and addressing societal challenges in this Leptoukh Lecture. Delve into the world of data-intensive science, focusing on examples such as air quality impacts from forest fires. Learn about the crucial role of findable, accessible, interoperable, and reusable (FAIR) data in enabling new scientific discoveries. Examine the evolving scientific data enterprise and the need for better coordination in planning, management, and resource allocation. Discuss the importance of reliable long-term funding and cultural changes to elevate Science Data Infrastructure. Gain insights into collaborative community efforts like the Earth Science Information Partners (ESIP) and Openscapes, and their role in pushing the boundaries of scientific progress. Discover how putting data to work can move science forward in unprecedented ways, benefiting not only research but also national security and society at large.