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Explore the principles of large-scale architecture and the power of simplicity in this conference talk from YOW! 2022. Delve into the challenges of building and scaling distributed systems, drawing from real-world examples at Google and eBay. Learn about key architectural concepts such as simplicity, orthogonality, asynchrony, and feedback. Discover how to break down complex problems, compose separate concerns, and leverage events and caching for efficient system design. Gain actionable insights on maintaining and improving complex systems through quality feedback mechanisms. The talk covers eBay and Amazon architectures, simple components and interactions, implementing changes, and practical applications of these principles. Includes a Q&A session for further discussion on scaling your own systems.