Molecular Structure Extrapolation to Zero Dose with CryoEM - IPAM at UCLA

Explore a cutting-edge lecture on molecular structure extrapolation in cryo-electron microscopy (cryoEM) presented by Katerina Naydenova from the University of Cambridge at IPAM's Cryo-Electron Microscopy and Beyond Workshop. Delve into the innovative approach of zero-dose extrapolation, which addresses the challenges of radiation damage and particle movement in cryoEM imaging. Discover how this technique enhances the visualization of crucial structural features, including ligand binding, metal coordination, and lipid bilayers. Learn about the physical origins of specimen movement, strategies for its elimination, and the implementation of a new algorithm for 3D reconstruction. Gain insights into radiation damage effects on biological molecules and the implications for atomic model refinement in cryoEM studies.