Explore the intricacies of the Kallikrein-Kinin system and the production of bradykinin in this informative 18-minute video lecture. Delve into the role of high molecular weight kininogen as a plasma protein activating the intrinsic coagulation pathway and producing bradykinin. Learn about plasma kallikrein's function in activating factor XII and understand the components of the Kallikrein-Kinin system, including plasma and tissue kallikrein, and their respective kinins. Discover how angiotensin-converting enzyme (ACE) degrades bradykinin and the implications of ACE inhibitors on bradykinin levels. Gain insights into bradykinin's pro-inflammatory effects, including vasodilation and increased vessel permeability, which can lead to angioedema. This comprehensive overview provides valuable knowledge for medical and nursing students studying hematology, physiology, and pharmacology.
Overview
Syllabus
Kallikrein-Kinin​ System | Let’s Produce Bradykinin !
Taught by
Medicosis Perfectionalis