Classical Serotonergic Psychedelics' Acute Effects Induce Changes to Brain's Functional Hierarchy

Watch a 24-minute conference talk from the Models of Consciousness Conferences exploring how classical serotonergic psychedelics affect brain function across multiple timescales. Delve into the acute and long-term effects of psychedelics like psilocybin, LSD, and DMT on neural reorganization and information flow in the brain. Learn about a three-timescale framework for understanding psychedelic action: "fast time" neuronal dynamics, "slower time" plasticity mechanisms, and "ultraslow" metaplasticity changes. Examine a concrete definition of hierarchy that quantifies time asymmetry in information flow directionality, demonstrating how classical psychedelics decrease functional hierarchy. Discover proposed neurobiological mechanisms for slow and ultraslow psychedelic effects that open new avenues for empirical research into both therapeutic applications and changes in neurophenomenology.