Explore molecular techniques used in cancer diagnosis across cellular pathology subspecialties in this comprehensive talk. Learn about immunohistochemistry, methylation profiling, fluorescence in situ hybridisation (FISH), and various sequencing modalities. Discover the advantages of each technique for pathologists in accurately characterizing tumors and identifying patients suitable for targeted therapies. Delve into topics such as tissue assessment, DNA mutations, DNA methylation in neuropathology, challenges in methylation profiling, DNA copy number interpretation, fusion translocations, and sequencing examples in sarcomas and brain tumors. Gain insights into improved diagnostic methods and their applications in different cancer types.
Introduction into Molecular Methods in Cancer Diagnosis - Dr. Matthew Clarke
The Royal College of Pathologists via YouTube
Overview
Syllabus
Introduction
Overview
Tissue assessment
DNA and mutations
Immunist chemistry
Summary
DNA Methylation
DNA Methylation in Neuropathology
Improved Diagnosis
Summary of methylation profiling
Challenges of methylation profiling
DNA copy number interpretation
Copy number plot
Copy number profile
Fusions translocations
Types of fusions
Definition of a fusion
Entrac fusions
Ntracks
Sequencing
Example
Sarcoma
Brain tumors
Fluorescence in situ hybridization
PCR
Taught by
The Royal College of Pathologists
Reviews
5.0 rating, based on 2 Class Central reviews
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Great course very helpful. Used evidence based methods and covered the basics of molecular methods. Delivery was well paced and the content was appropriate. Thanks
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Very interesting! Perhaps you could have linked in more examples of non-oncological pathologies, or of non-neurological neoplasms.
