Impact of Cell Background on Small Compound Target Deconvolution by CETSA Coupled to Mass Spectrometry

Explore the impact of cell background on small compound target deconvolution through a 43-minute webinar presented by Tomas Friman and Daniel Martinez Molina. Delve into the cellular thermal shift assay (CETSA), a powerful tool for confirming target engagement and deconvoluting mode of action in living cells. Learn how CETSA works by assessing changes in thermal stability of ligated proteins when comparing ligand-treated cells to non-treated cells after heat challenge. Gain insights into the application of CETSA coupled with mass spectrometry for small compound target deconvolution and understand how cell background influences this process.