How Ozempic and Wegovy Work - Understanding Semaglutide's Mechanism of Action

Learn about the mechanism of action and side effects of Semaglutide (marketed as Ozempic and Wegovy) in this comprehensive medical lecture. Explore how these synthetic GLP-1 molecules function in treating type II diabetes mellitus and promoting weight loss in obese and overweight individuals. Discover the drug's role in cardiac event protection, its effects on gastric emptying through vagal afferent pathways, and its interaction with the central parasympathetic system. Gain detailed insights into the biological processes involving L-cells, incretin hormones, and hypothalamic circuits that regulate appetite and energy homeostasis. Understand the potential side effects and management strategies while learning about the FDA approvals and clinical applications of these medications in modern medicine.