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Explore two innovative projects leveraging Ubuntu and MicroK8s in this conference talk from Ubuntu Summit 2023. Dive into a pilot project at the San Diego Supercomputer Center (SDSC) that migrated the Research Collaboratory for Structural Bioinformatics (RCSB) Protein Data Bank from OpenStack to Kubernetes, utilizing MicroK8s to create a sandbox environment for testing solutions. Learn how this approach preserved crucial fundraising data and facilitated a smooth transition for the RCSB PDB software, a vital search engine supporting global scientific research and education. Discover intriguing use cases demonstrating MicroK8s' role in migrating an in-house analytics engine essential for grant proposals. Then, examine a slow-control system project for a portable X-Ray spectrometer at the Center of Free Electron Lasers (CFEL) in Germany, implemented using Raspberry Pi 4 devices running Ubuntu and MicroK8s. Gain insights into the complex software and hardware components of this cutting-edge project, showcasing the versatility and power of Ubuntu and MicroK8s in advanced scientific applications.