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Explore groundbreaking advancements in autonomous interactive real-time systems through this insightful conference talk by Professor Marios Kountouris. Delve into a new theory aimed at revolutionizing cyber-physical mission-critical systems like robotics, self-driving cars, and IoT. Discover the vision of intelligent systems seamlessly interacting, processing, learning, sensing, and communicating in real-time. Examine the challenges of scalability and efficient data processing in high-density environments, using the example of autonomous cars in Paris. Learn about the concept of semantic communication and its focus on data significance for achieving specific goals. Understand the proposed goal-oriented semantic communication model that optimizes data generation, transmission, and processing to meet application needs while conserving resources. Gain insights into the historical foundations of communication theory and novel ideas about time and synchronization in information transmission. Ideal for those interested in the future of autonomous systems, real-time data processing, and next-generation communication theories.