Explore the transformative impact of genomics, imaging, and artificial intelligence on biological research and clinical practice in this comprehensive seminar hosted by the National Human Genome Research Institute. Delve into the technological advancements of the past two decades, examining how these three key areas have become fundamental to understanding living systems. Journey through examples from the European Molecular Biology Laboratory, uncovering both groundbreaking biological discoveries and practical clinical applications. Gain valuable insights into the future of these technologies, including the immense opportunities they present, the necessary data and skill requirements, and potential challenges to navigate. Engage with topics such as deep learning in protein folding, global biodata initiatives, and the evolution of the scientific workforce. Conclude with real-world examples demonstrating the profound impact of these technologies on both basic research and clinical operations, followed by an informative Q&A session.
Overview
Syllabus
- Introduction Eric Green
- Opening Remarks Ewan Birney
- About the European Molecular Biology Laboratory EMBL
- Current challenge in life sciences
- Understanding biology: same approach since the 1960s!
- Successive technology innovation
- Axes of improvement
- What has this enabled?
- Scientific services: Imaging across scales
- Three examples of new imaging modalities
- AI / Machine Learning
- Deep Learning
- Key elements for AI
- "Labelling" deep learning
- AlphaFold: accelerating scientific discovery in protein folding
- Deep learning by alternative maths infrastructure
- Open, organised fundamental biomolecular data
- Data resources at EMBL-EBI
- Global BioData Coalition
- Secondary use of genomics and imaging from Healthcare
- Computing environments: hardware GPUs with optimised data access
- Global Alliance for Genomics and Health GA4GH
- GA4GH in a Global Learning Health System
- Evolving the workforce
- Example 1 basic research ; The Nuclear Pore
- Example 2 Clinical operations
- Examples of profound changes in outcome
- Questions and Answers
Taught by
National Human Genome Research Institute
