Dive into a 33-minute beginner-friendly lecture on genomic inbreeding, part of a comprehensive genomics theory series. Explore the definition of inbreeding and its identification at the genomic level through runs of homozygosity (ROH). Understand the differences between identity-by-state and identity-by-descent, and learn about the inbreeding coefficient. Discover how ROH segments can be used to detect selection signatures and identify regions affected by recessive disorders. Follow along as the lecture covers pedigree vs. ROH inbreeding comparisons, genomic inbreeding coefficient calculations, and the relationship between ROH length and common ancestor distance. Access additional resources, including the full video playlist and PowerPoint presentations, to enhance your understanding of this fundamental genomics concept.
Overview
Syllabus
- Summary from previous lectures
- What is inbreeding?
- Identity by descent and by state IBD vs IBS
- Consequences and measurement of inbreeding
- Runs of homozygosity ROH
- Comparison of pedigree vs ROH inbreeding in half-sib mating
- Calculation of genomic inbreeding coefficient based on ROH
- Lenth of ROH and the distance to the common ancestor
- ROH islands selection signature
- Use of ROH to detect genomic regions with recessive disorders
- Summary of the lecture
Taught by
Genomics Boot Camp
