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Explore the impact of genetic variation in the ER-stress kinase PERK gene on stress tolerance in neurons and glia during this hour-long seminar. Delve into the potential connection between these genetic variations and HIV-associated changes in the central nervous system. Join Dr. Kelly Jordan-Sciutto from the University of Pennsylvania as she presents her research findings as part of the Joint NIMH Center Seminar Series. Gain insights into how alterations in stress tolerance mechanisms may contribute to neurological complications in HIV patients and discover potential new avenues for understanding and addressing HIV-related CNS disorders.