Explore the critical yet often overlooked genetic condition of familial hypercholesterolemia (FH) in this informative 48-minute lecture by Dr. Joshua W. Knowles from Stanford University. Learn about the genetic predisposition to extremely high LDL cholesterol levels, its potential for causing premature fatal heart attacks, and the effective statin-based therapies available. Discover why 90% of FH patients are unaware of their condition and the challenges in physician awareness and patient screening. Delve into the familial aspects of FH, new research for early diagnosis, and the importance of early intervention. Gain insights into FH treatments, including medications and lifestyle modifications, as well as the role of genetic testing and initiatives like the FH Foundation in improving diagnosis and care. Understand the significance of cholesterol levels, physical exam findings, and the liver's role in FH. Explore cutting-edge topics such as PCSK9 inhibitors, machine learning applications, and ongoing research efforts to combat this potentially life-threatening condition.
Overview
Syllabus
Intro
Pre Talk Quiz
Case
Medications
What is FH
No one knows about FH
If we start treatment
Cholesterol graph
Cholesterol levels
Physical exam findings
What causes FH
The liver and FH
Genetic testing for FH
CDC ranking of FH
FH treatment
FH in children
Optimal cholesterol levels
PCSK9 inhibitors
No active registry
FH Foundation
Patient Participation in Research
Average Age of Diagnosis
HDL
FH Patients
Find FH Initiative
Big Data
Selfie
Machine Learning
Post Talk Quiz
Survey Results
Pediatric Guidelines
Getting a Code
Other Consequences
Education
Exercise
New Drugs
Tissue Engineering
Diet and Exercise
HDL and Heart Disease
FH and Heart Disease
FH and Cholesterol
Taught by
Stanford Health Care
