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Explore the complex challenges facing the US Food and Drug Administration in this 52-minute talk featuring FDA Commissioner Robert Califf. Gain insights into the agency's oversight of $2.7 trillion in medical products, food, and tobacco, representing one-fifth of the nation's economy. Delve into pressing issues such as artificial intelligence, breakthrough pharmaceuticals, misinformation, vaping, cigarette nicotine content, and critical drug shortages, including life-extending chemotherapies. Understand the strategic decision-making and cutting-edge scientific knowledge required to navigate these challenges. This conversation, part of Aspen Ideas: Health 2023, offers a unique perspective on the FDA's role in shaping public health and economic policies in the United States.