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Explore the potential of Noisy Intermediate-Scale Quantum (NISQ) devices in this comprehensive lecture from the ICTP-SAIFR School on Quantum Computation. Delivered by Enrique Solano, Professor at the University of the Basque Country and CEO of QUANVIA and KIPU QUANTUM, this 1-hour 25-minute talk delves into the concept of NISQ advantage and its implications for quantum computing. Gain insights into how these quantum devices, despite their limitations, can potentially outperform classical computers in specific tasks. Learn about the current state of NISQ technology, its challenges, and the promising applications that could revolutionize various fields. Understand the strategies being developed to harness the power of NISQ devices and the roadmap towards achieving practical quantum advantage. This lecture is an essential resource for researchers, students, and professionals interested in the cutting-edge developments of quantum computing and its near-term applications.