Emerging Role of Neuroinflammation in C9orf72-ALS

Explore the emerging role of neuroinflammation in C9orf72-ALS through this 43-minute webinar presented by Dr. Deepti Lall. Delve into the impact of C9orf72 repeat expansions on inherited amyotrophic lateral sclerosis/frontotemporal dementia (ALS/FTD) and their potential involvement in other neurodegenerative syndromes. Discover how C9orf72 deficiency affects microglial homeostasis, promoting an inflammatory state with an enhanced type I IFN signature. Learn about the age-dependent neuronal defects triggered by C9orf72-depleted microglia, including increased cortical synaptic pruning and its effects on learning and memory behaviors in mice. Examine the paradoxical relationship between C9orf72 deficient microglia and amyloid accumulation in mouse models, where enhanced synapse loss and neuronal deficits occur alongside improved plaque clearance. Gain insights into how altered microglial function due to decreased C9orf72 expression may contribute to neurodegeneration in repeat expansion carriers, independent of gain of function toxicities.