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A conference talk from PyBay 2023 explores how the Nix Package Manager can revolutionize Python development practices. Learn how to overcome common dependency management challenges and ensure reproducible development environments using Nix's declarative configuration approach. Discover practical implementations for streamlining package management, maintaining consistent environments across development stages, and handling complex dependency graphs with precision. Drawing from a decade of Python experience, explore real-world scenarios and hands-on examples that demonstrate Nix's capabilities in creating resilient virtual environments and simplifying the development workflow. Master techniques for integrating Nix into Python projects, enabling better collaboration and faster development cycles while avoiding common dependency pitfalls. Delivered at the single-track regional Python conference for the San Francisco Bay Area, this presentation offers valuable insights for both newcomers and experienced Python developers seeking to enhance their development practices.