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Explore a 22-minute conference talk from Models of Consciousness Conferences that delves into new theoretical and computational perspectives on Minimal Phenomenal Experience (MPE). Gain insights into the process of de-fabrication of experience through an algorithmic agent framework based on the Kolmogorov Theory of consciousness. Learn how agents create compressive models to navigate and predict their environment, incorporating concepts of experience structure, valence, and model confidence. Discover how this framework, which generalizes active inference, applies to both biological and artificial systems, particularly in understanding de-fabrication in meditation and psychedelic experiences. Examine the neurobiological implementation of disrupting model predictions and input data comparison through a neural mass model of physiological activity, aligned with predictive processing mechanisms.