Dynamical Modeling of Proliferative-Invasive Plasticity and IFNγ Signaling in Melanoma - Mechanisms of PD-L1 Expression Heterogeneity

Explore a 19-minute conference talk that delves into the dynamical modeling of proliferative-invasive plasticity and IFNγ signaling in melanoma, uncovering mechanisms behind PD-L1 expression heterogeneity. Presented by Seemadri Subhadarshini at The Fields Institute, this talk is part of the "Mathematics of the Hallmarks of Cancer" series scheduled for August 21, 2024. Gain insights into the complex interplay between melanoma cell behavior and immune system interactions, specifically focusing on the role of interferon-gamma signaling in shaping PD-L1 expression patterns. Discover how mathematical modeling techniques are applied to understand and predict the dynamics of cancer cell plasticity and its implications for immunotherapy responses.