Drug-Induced Resistance in Cancer Chemotherapy: Darwinian Selection vs Generation of Variation

Explore the complex dynamics of drug resistance in cancer treatment through this 28-minute lecture by Angelique Stephanou from the Centre national de la recherche scientifique (CNRS). Delve into the comparison between Darwinian selection and the combined processes of variation generation and selection in the context of cancer chemotherapy. Gain insights into the mathematical models used to understand these mechanisms as part of the "Mathematics of the Hallmarks of Cancer" series presented by the Fields Institute. Examine how drug-induced resistance develops and impacts the effectiveness of cancer treatments, offering a deeper understanding of the challenges faced in oncology.