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Explore the groundbreaking principles of brain-like computing in this 55-minute conference talk from Strange Loop 2012. Delve into Jeff Hawkins' insights on how the neocortex operates fundamentally differently from traditional computers. Discover the concept of sparse distributed representations, the basic units of information in brains, and learn how these representations are acquired and processed to construct predictive models from high-velocity sensory data streams. Gain an understanding of Numenta's streaming analytics engine, which is built on these brain-inspired principles. Contemplate the future of machine intelligence as Hawkins, founder of Numenta, shares his expertise and speculations on the evolving landscape of computational neuroscience and its potential impact on future computer architectures.