Cell Validation and Drug-Induced Liver Injury Using a Human Liver Microphysiological System

Explore the critical role of microphysiological systems in drug development through this 28-minute webinar presented by Christiana Skarlatopoulou, a scientist at CN Bio. Delve into the challenges of drug-induced liver injury (DILI) and learn how organ-on-a-chip technology can bridge the gap between preclinical testing and clinical trials. Discover the importance of using validated human liver cells in 3D assay formats to improve the predictability of drug responses. Gain insights into the clinical predictability of a Liver MPS using OOC-validated liver cells and a validation set of hepatotoxic compounds, including new drug modalities like ASOs. Understand how this innovative approach can potentially reduce drug attrition rates and enhance the safety and efficacy of new therapeutics.