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Explore the crucial role of ontology in interpreting and structuring reality through this 27-minute conference talk by Giancarlo Guizzardi, Full Professor at the University of Twente. Delve into the discipline of ontology and its practical applications in information systems. Examine a fascinating case study on the 9/11 events, highlighting the real-world implications of ontological analysis. Understand how every information system embodies a specific worldview and learn about the importance of semantic precision, ontological transparency, and cognitive tractability in building trustworthy systems. Address challenges in data integration and veracity, and consider the paradigm shift towards intelligent augmentation. Gain valuable insights through real-world examples illustrating the complexities and significance of ontological clarity in various domains, making this talk essential for students, researchers, and professionals interested in the intersection of philosophy, computer science, and practical ontology applications.