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Explore a comprehensive approach to creating high-performance C++ applications in this 58-minute conference talk. Delve into multi-level design issues, including the crucial role of domain knowledge, optimal selection of data structures and algorithms, and efficient memory allocation strategies. Examine the impact of modern machine architectures and caches on performance, and learn how to leverage move semantics for improved efficiency. Investigate various string handling techniques and their performance implications. Gain insights into effective measurement methodologies to quantify optimizations. Presented by Hubert Matthews at NDC Conferences, this talk provides a holistic view of C++ performance optimization beyond simple low-level tweaks.