C-ANCA vs P-ANCA - Autoantibodies | Autoimmune Diseases

Explore the world of anti-neutrophilic cytoplasmic antibodies (ANCA) in this informative 20-minute video. Delve into the differences between cytoplasmic ANCA (c-ANCA) and perinuclear ANCA (p-ANCA), understanding their role as IgG autoantibodies targeting neutrophil and monocyte cytoplasm. Learn how ANCA differs from antinuclear antibodies (ANA) and discover their association with various vasculitis conditions, including granulomatosis with polyangiitis, microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis. Gain insights into ANCA's connection to rapidly-progressive glomerulonephritis, anti-glomerular basement membrane antibodies, and inflammatory bowel disease-associated vasculitis. Understand the limitations of ANCA in correlating with disease activity or symptoms, enhancing your knowledge of autoimmune diseases and their diagnostic markers.