Explore cutting-edge techniques for imaging the anatomical and functional micro-organization of the brain in this 55-minute seminar presented by Dr. Nikolaus Weiskopf from the Max Planck Institute for Human Cognitive and Brain Sciences. Delve into advanced imaging methods such as multi-parameter mapping (MPM), in-vivo histology using MRI (hMRI), and high-field 7T MRI with motion correction. Discover how these techniques reveal intricate details of brain structure, including myelin distribution, iron content, and short association fibers. Learn about the correlation between quantitative MRI and histological findings, and how these imaging approaches can predict functional organization like retinotopy. Gain insights into the evolution of hominoid brain connectomics and the latest developments in microscopic resolution iron mapping. This comprehensive seminar covers a wide range of topics from basic principles to cutting-edge applications, making it valuable for neuroscientists, radiologists, and researchers interested in advanced neuroimaging techniques.
Overview
Syllabus
Introduction Due to technical issues, the slides are shown in the beginning
3:43 Importance of brain micro-organization Due to technical issues, there is echoing until ~
Micro-organization imaging and in-vivo histology using hMRI
Modelling strategy: multi-contrast, multi-Level
Three-pronged interdisciplinary approach
Overview
Multi-parameter mapping MPM using multi-echo FLASH
Multi-parameter maps MPM at 7T using optical prospective motion correction PMC
R1 myelin maps compared to fMRI retinotopy
Inter-areal feature: myelination of thin, thick and pale stripes in secondary visual cortex V2
Intra-areal features: stripes in secondary visual cortex V2
Complex Myelin: Histology compared to quantitative MRI
MALDI-Mass Spectrometry Imaging of lipid components
Imaging Superficial White Matter SWM
Quantitative Iron Maps Correlate with MR Contrast
Mapping oligodendrocytes and myelinated fibers
Mapping short association fibers SAF with 300mT/m Connectom MRI: visual system
Mapping short association fibers SAF: visual system
Mapping SAF: predicting retinotopic organization
SAF contribution to connective field sizes
Evolution of hominoid brain connectomics EBC
Quantitative 3D iron maps with microscopic resolution
N1 and the swallow tail overlay only partly N1 is thinner and extends beyond the swallow tail sign.
Discussion
Taught by
MGH Martinos Center
