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Explore cutting-edge biomedical informatics strategies for improving individualized predictive models in this keynote lecture delivered by Lucila Ohno-Machado at Yale University. Delve into the latest advancements and techniques used to enhance the accuracy and effectiveness of personalized healthcare predictions. Gain valuable insights into how data-driven approaches are revolutionizing patient care and treatment outcomes. This 47-minute presentation, part of the Deep Reconstruction Workshop held on March 24, 2023, offers a comprehensive overview of the intersection between biomedical informatics and predictive modeling, highlighting its potential to transform the future of medicine.